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    Apparence Solide Propriétés chimiques; Formule brute: C 22 H 30 N 6 O 4 S [Isomères]: Masse molaire [1]: 474,576 ± 0,027 g/mol C 55,68 %, H 6,37 %, N 17,71 %, O 13,49 %, S 6,76 %,

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    Sildenafil citrate is a potent, orally active phosphodiesterase 5 (PDE5) inhibitor (IC₅₀ = 4 nM). Inhibition of PDE5 enhances the relaxation of smooth muscle in a range of vascular tissues by prolonging the nitric oxide/cGMP-mediated activation of cGMP-de

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    2 Sildenafil-d8 CAS No. 171599-83-0(non-d) C22H22D8N6O4S M.W. 482.63 CSTS063 Sildenafil Dimer Impurity C38H46N10O8S2 M.W. 834.98 CSTS0630 Benzyl Sildenafil

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    Sildenafil is a selective inhibitor of PDE5 (type 5 cGMP phosphodiesterase) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small .

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