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    Xylazine is an analogue of clonidine and an agonist at the α 2 class of adrenergic receptor. It is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.Veterinarians also use xylazine as an emetic, especially in cats.

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    The dotted lines show the pre-xylazine glucose levels in normoglycemic and insulin-dependent diabetic monkeys. The time-dependent effects of xylazine on plasma insulin and glucagon are shown in panel B and C, respectively. ↑, the time point that xylazine (1–2 mg/kg) was injected intramuscularly. **, p

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    References. References are publications that support the biological activity of the product. Anis et al (1983) The dissociative anaesthetics, KA and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br.J.Pharmacol. 79 565 PMID: 6317114. Pallares et al (1995) Effects of KA, a noncompetitive NMDA antagonist, on the acquisition of the lever-press .

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    Xylazine significantly decreases heart rate, respiratory rate, rate of ruminal contractions, arterial blood pressure, PaO2, PCV, and total solids concentration, and significantly increases PaCO2, base excess, and bicarbonate concentration in cows.

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    XylaMed Xylazine HCl for Horses. Xylazine HCl Injection is also used as a pre-anesthetic to general anesthesia or in conjunction with local anesthetics. Contains 100 mg xylazine per ml. The dosage for Xylazine HCl Injection is recommended at 0.5 ml per 100 lbs body weight by IV administration, or 1.0 ml per 100 lbs body weight by IM administration. Xylazine.

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    Xylazine HCl Injection (xylazine) is tolerated in dogs and cats at 10 times the recommended dose. However, doses of this magnitude produce muscle tremors, emesis and long periods of sedation. Warning. This drug is for use in dogs and cats only.

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    Xylazine HCl Injection (xylazine) in horses and Cervidae, used at recommended dosage levels may occasionally cause slight muscle tremors, bradycardia with partial A-V heart block and a reduced respiratory rate. Movement in response to sharp auditory stimuli may be observed.

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    Xylazine HCl Indications. Xylazine should be used in horses and Cervidae (Fallow Deer, Mule Deer, Sika Deer, White-Tailed Deer and Elk) when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia.

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    Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor. It is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. Veterinarians also use xylazine as an emetic, especially in cats.

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